این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Research in Medical Sciences، جلد ۲۰۱۴، شماره ۰۱، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Efficacy of Prophylactic Low Dose of Tranexamic Acid in Spinal Fixation Surgery: A Randomized Clinical Trial
چکیده انگلیسی مقاله Background: Spinal fixation surgery is potentially associated with significant bleeding, often requiring multiple blood transfusions. Concern for the risks of transfusion-acquired infection and immune modulation effects of allogeneic blood has led to the investigation of various hemostatic agents such as tranexamic acid (TXA). The investigators hypothesized that a prophylactic low dose of TXA would reduce blood loss and transfusion requirements during spinal fixation surgery. Materials and Methods: Of 92 patients, 76 were eligible for participation: 38 patients underwent TXA (10 mg/kg) at the initiation of induction of anesthesia during 10 min followed by intravenous infusion of 1 mg/kg/h (TXA group) and 38 patients received normal saline (control group). General anesthesia was administered and different hemodynamic parameters, complete blood count, abnormal prothrombin time, partial thromboplastin time, fibrinogen level, electrolytes, blood loss, and complications were assessed. Results: Amount of blood transfused to the TXA group (n=10; 675±382 mL) compared with the control group (n=15; 600±220 mL) was not statistically significant (P=0.539). Total intraoperative blood loss was not significantly reduced in the TXA group compared with the control group (1269±690 vs. 1336±550 mL; P=0.659). In the 2 groups, fibrinogen level changed to the same extent and platelet count was reduced. Trend of changes in sodium, potassium, and calcium was the same in either group. No thromboembolic complications were clinically detected in either group. Conclusions: The administration of a prophylactic low dose of TXA did not have a significant effect in the management of intraoperative blood loss and transfusion requirements in patients undergoing spinal fixation surgery. Normal 0 false false false EN-US X-NONE AR-SA
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مجید رضا فرخی | majid reza farrokhi
professor of neurosurgery, shiraz neurosciences research center, neurosurgery department, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9669
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات